Medical Aesthetics Clinic

Polynucleotide Injectable Treatments

Polynucleotides (PDRN) are bio-stimulators backed by over 90 scientific papers — working at a cellular level to stimulate tissue repair and collagen production. This is not a trend treatment. It has a genuine and substantial evidence base.

Book Appointment

Advanced Bioregenerative Skin Repair & Skin Quality Enhancement

At The Aesthetic Medical Clinic we offer advanced polynucleotide injectable treatments designed to improve:
• Skin quality
• Hydration
• Elasticity
• Fine crepey texture
• Tissue regeneration support
• Under-eye rejuvenation

Polynucleotides are part of a growing class of regenerative injectable treatments that focus on improving the biological health of the skin rather than simply adding volume or temporary hydration.

They are particularly useful for patients seeking subtle, natural-looking improvement in skin quality over time.

What Are Polynucleotides?

Polynucleotides are highly purified DNA fragments, typically derived from salmon or trout DNA, which are biocompatible with human tissue.

They work differently from:
• Dermal fillers (which restore volume)
• Skin boosters (which primarily hydrate the skin)
• Anti-wrinkle injections (which relax muscles)

Instead, polynucleotides are designed to support:

Tissue repair and skin regeneration
They are best understood as a biostimulatory, regenerative injectable rather than a volumising or purely hydrating treatment.

Book Appointment

How Do Polynucleotides Work?

Polynucleotides are thought to improve skin quality through several mechanisms:

1. Hydration and Water Binding
They attract and retain water within the dermal matrix, improving:
• Skin hydration
• Elasticity
• Suppleness
• Smoothness

2. Fibroblast Activation
They may stimulate fibroblasts, the cells responsible for producing:
• Collagen
• Elastin
• Extracellular matrix components

This contributes to gradual improvement in:
• Skin texture
• Firmness
• Dermal quality

3. Tissue Repair & Regeneration
Polynucleotides may help optimise the skin’s healing environment by:
• Supporting cellular repair processes
• Modulating inflammation
• Reducing oxidative stress
• Enhancing extracellular matrix stability

4. Skin Quality Improvement
Rather than producing volume, polynucleotides aim to improve:
• Skin resilience
• Thickness
• Elasticity
• Overall skin health

Results are typically subtle but progressively improving.

What Areas Can Be Treated?

Polynucleotides are commonly used for:
• Under-eye area (tear trough skin quality)
• Face
• Neck
• Décolletage
• Hands

They are particularly effective in areas with:
• Thin or crepey skin
• Early ageing changes
• Loss of elasticity
• Skin fragility

Where Do Polynucleotides Fit in Modern Skin Rejuvenation?

At The Aesthetic Medical Clinic we offer a full range of advanced skin treatments including:
• Polynucleotides
• Skin boosters
• Anti-wrinkle injections
• IPL
• Q-switched Nd:YAG laser
• Fractional laser resurfacing (AUREON Dual)
• Fractional CO2 resurfacing
Each treatment addresses a different layer of skin ageing.

Polynucleotides are particularly useful for:

• Improving overall skin quality
• Supporting fragile or crepey skin
• Under-eye rejuvenation
• Maintenance regenerative therapy

Skin boosters are generally better for:

• Rapid hydration
• Immediate glow
• Short-term skin plumping

Fractional laser treatments are stronger for:

• Collagen remodelling
• Wrinkles
• Acne scars
• Structural skin improvement

CO2 laser resurfacing is best for:

• Advanced ageing
• Significant wrinkles
• Deep textural damage
• Dramatic resurfacing

Treatment Experience

Polynucleotide treatment involves a series of small injections placed into the skin using fine needles or cannula techniques.
A typical session lasts:
• 20–40 minutes
Topical anaesthetic may be used to improve comfort, particularly for under-eye treatment.

Downtime

Downtime is usually minimal.
Possible temporary effects include:
• Small injection bumps
• Mild swelling
• Bruising
• Redness
These typically settle within a few days.

How Many Treatments Are Needed?

Most patients benefit from an initial course of:
• 2–3 treatments
followed by maintenance sessions depending on skin quality and treatment goals.

When Will I See Results?

Results are typically:
• Gradual
• Subtle
• Progressive

Patients often notice improvements in:
• Skin hydration
• Texture
• Elasticity
• Overall skin quality
over several weeks to months.

Are Polynucleotides Permanent?

Polynucleotides are not permanent fillers.
They work by stimulating biological processes within the skin, and their effects gradually diminish over time, which is why maintenance treatments are often recommended.

Frequently Asked Questions — Polynucleotides

  • What are polynucleotides?

    Polynucleotides are injectable DNA fragments used to improve skin quality by supporting hydration, tissue repair, and regenerative skin processes.

  • Are polynucleotides the same as fillers?

    No.

    Fillers restore volume and contour, while polynucleotides aim to improve:
    • Skin quality
    • Hydration
    • Elasticity
    • Tissue health

    They do not significantly change facial structure.

  • What do polynucleotides actually do?

    They are thought to:
    • Improve hydration
    • Support fibroblast activity
    • Enhance tissue repair
    • Improve skin elasticity and resilience

    They work gradually rather than instantly.

  • How quickly do they work?

    Some patients notice early improvements in hydration within days, but most benefits develop gradually over:

    • Several weeks to months

  • Are results immediate like skin boosters?

    No.
    Skin boosters provide more immediate hydration and glow.
    Polynucleotides are slower but potentially more regenerative in nature.

  • Do polynucleotides stimulate collagen?

    Yes, they may stimulate fibroblasts, which produce collagen and elastin, but the effect is typically subtle and gradual rather than dramatic.

  • What areas are best for treatment?

    They are especially effective for:
    • Under-eye skin quality
    • Crepey facial skin
    • Neck skin
    • Décolletage
    • Hands

  • Are polynucleotides safe?

    When used appropriately by qualified medical professionals, polynucleotides have a good safety profile.
    Temporary effects may include:
    • Swelling
    • Bruising
    • Injection site tenderness

  • How do polynucleotides compare with lasers?

    Fractional lasers (such as CO2 or AUREON Dual) provide stronger structural improvement for:
    • Wrinkles
    • Acne scars
    • Texture changes

    Polynucleotides are gentler and focus on:
    • Skin quality
    • Hydration
    • Tissue support

    They are often complementary rather than competing treatments.

  • Can polynucleotides be combined with other treatments?

    Yes — they are frequently combined with:
    • Skin boosters
    • Anti-wrinkle injections
    • IPL
    • Fractional laser resurfacing
    • CO2 laser resurfacing
    • Medical skincare
    Combination treatment often provides the best overall skin rejuvenation outcomes.

  • Why choose your clinic for polynucleotides?

    Patients choose The Aesthetic Medical Clinic because we offer:
    • Consultant-led aesthetic assessment
    • Full range of regenerative and laser treatments
    • Expertise in facial ageing and skin biology
    • Integration of surgical and non-surgical approaches
    • Tailored treatment planning based on skin condition and goals

    Our approach focuses on selecting the right tool for the right layer of facial ageing — whether that is hydration, regeneration, resurfacing, or structural rejuvenation.

Polynucleotides in Bristol (PDRN)

Polynucleotides, also known as PDRN (polydeoxyribonucleotide), represent one of the most clinically supported advances in aesthetic medicine in recent years. Derived from highly purified salmon DNA, they work at a cellular level to stimulate tissue repair, collagen production, and skin regeneration. The products we use at our Clifton, Bristol clinic are backed by over 90 scientific papers and 34 clinical trials from Mastelli Aesthetics.

This is not a trend treatment. It is a treatment with a genuine and substantial evidence base. Unlike skin boosters, which primarily deliver hydration, polynucleotides act as bio-stimulators. They stimulate fibroblasts, the cells responsible for producing collagen and elastin, encourage the formation of new micro-blood vessels, improve water balance regulation, and reduce inflammation.

What Polynucleotides Treat at Our Bristol Clinic

• Dull or fatigued-looking skin
• Fine lines and early wrinkles
• Pigmentation and uneven skin tone
• Acne scarring and surface scarring
• Crepey skin around the eyes, one of the most effective applications
• Hair loss, scalp injections can stimulate follicle activity

Frequently Asked Questions, Polynucleotides Bristol

Are polynucleotides the same as PDRN?
Yes, PDRN (polydeoxyribonucleotide) is the scientific name for the active ingredient in polynucleotide treatments.

How many sessions are needed?
Most patients begin with a course of 3 sessions. Hair restoration typically requires more, up to 8 sessions.

Can polynucleotides be used around the eyes?
Yes, and this is one of their most valuable applications, safely addressing fine, crepey skin in a way very few other injectable treatments can achieve.

Are there any side effects?
Some temporary redness and minor bruising at injection sites is normal. Full aftercare guidance is provided at your appointment at our Bristol clinic.